Data harmonization and federated analysis of population-based studies: the BioSHaRE project
Identifieur interne : 000359 ( Main/Exploration ); précédent : 000358; suivant : 000360Data harmonization and federated analysis of population-based studies: the BioSHaRE project
Auteurs : Dany Doiron [Canada] ; Paul Burton [Royaume-Uni] ; Yannick Marcon [Canada] ; Amadou Gaye [Royaume-Uni] ; Bruce H R. Wolffenbuttel [Pays-Bas] ; Markus Perola [Finlande] ; Ronald P. Stolk [Pays-Bas] ; Luisa Foco [Italie] ; Cosetta Minelli [Royaume-Uni] ; Melanie Waldenberger [Allemagne] ; Rolf Holle [Allemagne] ; Kirsti Kval Y [Norvège] ; Hans L. Hillege [Pays-Bas] ; Anne-Marie Tassé [Canada] ; Vincent Ferretti [Canada] ; Isabel Fortier [Canada]Source :
- Emerging Themes in Epidemiology [ 1742-7622 ] ; 2013.
Abstract
Individual-level data pooling of large population-based studies across research centres in international research projects faces many hurdles. The BioSHaRE (Biobank Standardisation and Harmonisation for Research Excellence in the European Union) project aims to address these issues by building a collaborative group of investigators and developing tools for data harmonization, database integration and federated data analyses.
Eight population-based studies in six European countries were recruited to participate in the BioSHaRE project. Through workshops, teleconferences and electronic communications, participating investigators identified a set of 96 variables targeted for harmonization to answer research questions of interest. Using each study’s questionnaires, standard operating procedures, and data dictionaries, harmonization potential was assessed. Whenever harmonization was deemed possible, processing algorithms were developed and implemented in an open-source software infrastructure to transform study-specific data into the target (i.e. harmonized) format. Harmonized datasets located on server in each research centres across Europe were interconnected through a federated database system to perform statistical analysis.
Retrospective harmonization led to the generation of common format variables for 73% of matches considered (96 targeted variables across 8 studies). Authenticated investigators can now perform complex statistical analyses of harmonized datasets stored on distributed servers without actually sharing individual-level data using the DataSHIELD method.
New Internet-based networking technologies and database management systems are providing the means to support collaborative, multi-center research in an efficient and secure manner. The results from this pilot project show that, given a strong collaborative relationship between participating studies, it is possible to seamlessly co-analyse internationally harmonized research databases while allowing each study to retain full control over individual-level data. We encourage additional collaborative research networks in epidemiology, public health, and the social sciences to make use of the open source tools presented herein.
Url:
DOI: 10.1186/1742-7622-10-12
PubMed: 24257327
PubMed Central: 4175511
Affiliations:
- Allemagne, Canada, Finlande, Italie, Norvège, Pays-Bas, Royaume-Uni
- Angleterre, Grand Londres, Groningue (province), Québec, Trøndelag, Uusimaa
- Groningue, Helsinki, Londres, Montréal, Trondheim
- Université d'Helsinki, Université de Groningue
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Stolk</name><affiliation wicri:level="3"><nlm:aff id="I8">Department of Epidemiology, University Medical Center Groningen, Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, University Medical Center Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Foco, Luisa" sort="Foco, Luisa" uniqKey="Foco L" first="Luisa" last="Foco">Luisa Foco</name><affiliation wicri:level="1"><nlm:aff id="I9">European Academy of Bolzano/Bozen (EURAC), Center for Biomedicine, Bolzano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>European Academy of Bolzano/Bozen (EURAC), Center for Biomedicine, Bolzano</wicri:regionArea><wicri:noRegion>Bolzano</wicri:noRegion></affiliation></author><author><name sortKey="Minelli, Cosetta" sort="Minelli, Cosetta" uniqKey="Minelli C" first="Cosetta" last="Minelli">Cosetta Minelli</name><affiliation wicri:level="3"><nlm:aff id="I13">Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Waldenberger, Melanie" sort="Waldenberger, Melanie" uniqKey="Waldenberger M" first="Melanie" last="Waldenberger">Melanie Waldenberger</name><affiliation wicri:level="1"><nlm:aff id="I10">Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Holle, Rolf" sort="Holle, Rolf" uniqKey="Holle R" first="Rolf" last="Holle">Rolf Holle</name><affiliation wicri:level="1"><nlm:aff id="I10">Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Kval Y, Kirsti" sort="Kval Y, Kirsti" uniqKey="Kval Y K" first="Kirsti" last="Kval Y">Kirsti Kval Y</name><affiliation wicri:level="3"><nlm:aff id="I11">Department of Public Health and General Practice, HUNT Research Center, Norwegian University of Science and Technology, Trondheim, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Public Health and General Practice, HUNT Research Center, Norwegian University of Science and Technology, Trondheim</wicri:regionArea><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation></author><author><name sortKey="Hillege, Hans L" sort="Hillege, Hans L" uniqKey="Hillege H" first="Hans L" last="Hillege">Hans L. Hillege</name><affiliation wicri:level="3"><nlm:aff id="I12">Department of Cardiology and Epidemiology, University Medical Centre Groningen, Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology and Epidemiology, University Medical Centre Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Tasse, Anne Marie" sort="Tasse, Anne Marie" uniqKey="Tasse A" first="Anne-Marie" last="Tassé">Anne-Marie Tassé</name><affiliation wicri:level="3"><nlm:aff id="I2">Public Population Project in Genomics and Society, Montreal, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Public Population Project in Genomics and Society, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Ferretti, Vincent" sort="Ferretti, Vincent" uniqKey="Ferretti V" first="Vincent" last="Ferretti">Vincent Ferretti</name><affiliation wicri:level="1"><nlm:aff id="I3">Ontario Institute for Cancer Research, MaRS Centre, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Ontario Institute for Cancer Research, MaRS Centre, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Fortier, Isabel" sort="Fortier, Isabel" uniqKey="Fortier I" first="Isabel" last="Fortier">Isabel Fortier</name><affiliation wicri:level="1"><nlm:aff id="I1">Research Institute of the McGill University Health Centre, 2155 Guy, office 458, Montreal, Quebec H3H 2R9, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Research Institute of the McGill University Health Centre, 2155 Guy, office 458, Montreal, Quebec H3H 2R9</wicri:regionArea><wicri:noRegion>Quebec H3H 2R9</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24257327</idno><idno type="pmc">4175511</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175511</idno><idno type="RBID">PMC:4175511</idno><idno type="doi">10.1186/1742-7622-10-12</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000336</idno><idno type="wicri:Area/Pmc/Curation">000336</idno><idno type="wicri:Area/Pmc/Checkpoint">000338</idno><idno type="wicri:Area/Ncbi/Merge">000475</idno><idno type="wicri:Area/Ncbi/Curation">000475</idno><idno type="wicri:Area/Ncbi/Checkpoint">000475</idno><idno type="wicri:Area/Main/Merge">000360</idno><idno type="wicri:Area/Main/Curation">000359</idno><idno type="wicri:Area/Main/Exploration">000359</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Data harmonization and federated analysis of population-based studies: the BioSHaRE project</title><author><name sortKey="Doiron, Dany" sort="Doiron, Dany" uniqKey="Doiron D" first="Dany" last="Doiron">Dany Doiron</name><affiliation wicri:level="1"><nlm:aff id="I1">Research Institute of the McGill University Health Centre, 2155 Guy, office 458, Montreal, Quebec H3H 2R9, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Research Institute of the McGill University Health Centre, 2155 Guy, office 458, Montreal, Quebec H3H 2R9</wicri:regionArea><wicri:noRegion>Quebec H3H 2R9</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="I2">Public Population Project in Genomics and Society, Montreal, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Public Population Project in Genomics and Society, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Burton, Paul" sort="Burton, Paul" uniqKey="Burton P" first="Paul" last="Burton">Paul Burton</name><affiliation wicri:level="1"><nlm:aff id="I4">D2K Research Group, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>D2K Research Group, School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Marcon, Yannick" sort="Marcon, Yannick" uniqKey="Marcon Y" first="Yannick" last="Marcon">Yannick Marcon</name><affiliation wicri:level="1"><nlm:aff id="I1">Research Institute of the McGill University Health Centre, 2155 Guy, office 458, Montreal, Quebec H3H 2R9, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Research Institute of the McGill University Health Centre, 2155 Guy, office 458, Montreal, Quebec H3H 2R9</wicri:regionArea><wicri:noRegion>Quebec H3H 2R9</wicri:noRegion></affiliation></author><author><name sortKey="Gaye, Amadou" sort="Gaye, Amadou" uniqKey="Gaye A" first="Amadou" last="Gaye">Amadou Gaye</name><affiliation wicri:level="1"><nlm:aff id="I4">D2K Research Group, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>D2K Research Group, School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Wolffenbuttel, Bruce H R" sort="Wolffenbuttel, Bruce H R" uniqKey="Wolffenbuttel B" first="Bruce H R" last="Wolffenbuttel">Bruce H R. Wolffenbuttel</name><affiliation wicri:level="4"><nlm:aff id="I5">Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName><orgName type="university">Université de Groningue</orgName></affiliation></author><author><name sortKey="Perola, Markus" sort="Perola, Markus" uniqKey="Perola M" first="Markus" last="Perola">Markus Perola</name><affiliation wicri:level="1"><nlm:aff id="I6">Department of Chronic Disease Prevention, Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Chronic Disease Prevention, Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="I7">Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Stolk, Ronald P" sort="Stolk, Ronald P" uniqKey="Stolk R" first="Ronald P" last="Stolk">Ronald P. Stolk</name><affiliation wicri:level="3"><nlm:aff id="I8">Department of Epidemiology, University Medical Center Groningen, Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, University Medical Center Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Foco, Luisa" sort="Foco, Luisa" uniqKey="Foco L" first="Luisa" last="Foco">Luisa Foco</name><affiliation wicri:level="1"><nlm:aff id="I9">European Academy of Bolzano/Bozen (EURAC), Center for Biomedicine, Bolzano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>European Academy of Bolzano/Bozen (EURAC), Center for Biomedicine, Bolzano</wicri:regionArea><wicri:noRegion>Bolzano</wicri:noRegion></affiliation></author><author><name sortKey="Minelli, Cosetta" sort="Minelli, Cosetta" uniqKey="Minelli C" first="Cosetta" last="Minelli">Cosetta Minelli</name><affiliation wicri:level="3"><nlm:aff id="I13">Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Waldenberger, Melanie" sort="Waldenberger, Melanie" uniqKey="Waldenberger M" first="Melanie" last="Waldenberger">Melanie Waldenberger</name><affiliation wicri:level="1"><nlm:aff id="I10">Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Holle, Rolf" sort="Holle, Rolf" uniqKey="Holle R" first="Rolf" last="Holle">Rolf Holle</name><affiliation wicri:level="1"><nlm:aff id="I10">Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Kval Y, Kirsti" sort="Kval Y, Kirsti" uniqKey="Kval Y K" first="Kirsti" last="Kval Y">Kirsti Kval Y</name><affiliation wicri:level="3"><nlm:aff id="I11">Department of Public Health and General Practice, HUNT Research Center, Norwegian University of Science and Technology, Trondheim, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Public Health and General Practice, HUNT Research Center, Norwegian University of Science and Technology, Trondheim</wicri:regionArea><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation></author><author><name sortKey="Hillege, Hans L" sort="Hillege, Hans L" uniqKey="Hillege H" first="Hans L" last="Hillege">Hans L. Hillege</name><affiliation wicri:level="3"><nlm:aff id="I12">Department of Cardiology and Epidemiology, University Medical Centre Groningen, Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology and Epidemiology, University Medical Centre Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Tasse, Anne Marie" sort="Tasse, Anne Marie" uniqKey="Tasse A" first="Anne-Marie" last="Tassé">Anne-Marie Tassé</name><affiliation wicri:level="3"><nlm:aff id="I2">Public Population Project in Genomics and Society, Montreal, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Public Population Project in Genomics and Society, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Ferretti, Vincent" sort="Ferretti, Vincent" uniqKey="Ferretti V" first="Vincent" last="Ferretti">Vincent Ferretti</name><affiliation wicri:level="1"><nlm:aff id="I3">Ontario Institute for Cancer Research, MaRS Centre, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Ontario Institute for Cancer Research, MaRS Centre, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Fortier, Isabel" sort="Fortier, Isabel" uniqKey="Fortier I" first="Isabel" last="Fortier">Isabel Fortier</name><affiliation wicri:level="1"><nlm:aff id="I1">Research Institute of the McGill University Health Centre, 2155 Guy, office 458, Montreal, Quebec H3H 2R9, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Research Institute of the McGill University Health Centre, 2155 Guy, office 458, Montreal, Quebec H3H 2R9</wicri:regionArea><wicri:noRegion>Quebec H3H 2R9</wicri:noRegion></affiliation></author></analytic><series><title level="j">Emerging Themes in Epidemiology</title><idno type="eISSN">1742-7622</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Abstracts</title><sec><title>Background</title><p>Individual-level data pooling of large population-based studies across research centres in international research projects faces many hurdles. The BioSHaRE (Biobank Standardisation and Harmonisation for Research Excellence in the European Union) project aims to address these issues by building a collaborative group of investigators and developing tools for data harmonization, database integration and federated data analyses.</p></sec><sec><title>Methods</title><p>Eight population-based studies in six European countries were recruited to participate in the BioSHaRE project. Through workshops, teleconferences and electronic communications, participating investigators identified a set of 96 variables targeted for harmonization to answer research questions of interest. Using each study’s questionnaires, standard operating procedures, and data dictionaries, harmonization potential was assessed. Whenever harmonization was deemed possible, processing algorithms were developed and implemented in an open-source software infrastructure to transform study-specific data into the target (i.e. harmonized) format. Harmonized datasets located on server in each research centres across Europe were interconnected through a federated database system to perform statistical analysis.</p></sec><sec><title>Results</title><p>Retrospective harmonization led to the generation of common format variables for 73% of matches considered (96 targeted variables across 8 studies). Authenticated investigators can now perform complex statistical analyses of harmonized datasets stored on distributed servers without actually sharing individual-level data using the DataSHIELD method.</p></sec><sec><title>Conclusion</title><p>New Internet-based networking technologies and database management systems are providing the means to support collaborative, multi-center research in an efficient and secure manner. The results from this pilot project show that, given a strong collaborative relationship between participating studies, it is possible to seamlessly co-analyse internationally harmonized research databases while allowing each study to retain full control over individual-level data. We encourage additional collaborative research networks in epidemiology, public health, and the social sciences to make use of the open source tools presented herein.</p></sec></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Smith Warner, Sa" uniqKey="Smith Warner S">SA Smith-Warner</name></author><author><name sortKey="Spiegelman, D" uniqKey="Spiegelman D">D Spiegelman</name></author><author><name sortKey="Ritz, J" uniqKey="Ritz J">J Ritz</name></author><author><name sortKey="Albanes, D" uniqKey="Albanes D">D Albanes</name></author><author><name sortKey="Beeson, Wl" uniqKey="Beeson W">WL Beeson</name></author><author><name sortKey="Bernstein, L" uniqKey="Bernstein L">L Bernstein</name></author><author><name sortKey="Berrino, F" uniqKey="Berrino F">F Berrino</name></author><author><name sortKey="Van Den Brandt, Pa" uniqKey="Van Den Brandt P">PA van den Brandt</name></author><author><name sortKey="Buring, Je" uniqKey="Buring J">JE Buring</name></author><author><name sortKey="Cho, E" uniqKey="Cho E">E Cho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thompson, A" uniqKey="Thompson A">A Thompson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khoury, Mj" uniqKey="Khoury M">MJ Khoury</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hamilton, Cm" uniqKey="Hamilton C">CM Hamilton</name></author><author><name sortKey="Strader, Lc" uniqKey="Strader L">LC Strader</name></author><author><name sortKey="Pratt, Jg" uniqKey="Pratt J">JG Pratt</name></author><author><name sortKey="Maiese, D" uniqKey="Maiese D">D Maiese</name></author><author><name sortKey="Hendershot, T" uniqKey="Hendershot T">T Hendershot</name></author><author><name sortKey="Kwok, Rk" uniqKey="Kwok R">RK Kwok</name></author><author><name sortKey="Hammond, Ja" uniqKey="Hammond J">JA Hammond</name></author><author><name sortKey="Huggins, W" uniqKey="Huggins W">W Huggins</name></author><author><name sortKey="Jackman, D" uniqKey="Jackman D">D Jackman</name></author><author><name sortKey="Pan, H" uniqKey="Pan H">H Pan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Noale, M" uniqKey="Noale M">M Noale</name></author><author><name sortKey="Minicuci, N" uniqKey="Minicuci N">N Minicuci</name></author><author><name sortKey="Bardage, C" uniqKey="Bardage C">C Bardage</name></author><author><name sortKey="Gindin, J" uniqKey="Gindin J">J Gindin</name></author><author><name sortKey="Nikula, S" uniqKey="Nikula S">S Nikula</name></author><author><name sortKey="Pluijm, S" uniqKey="Pluijm S">S Pluijm</name></author><author><name sortKey="Rodriguez Laso, A" uniqKey="Rodriguez Laso A">A Rodríguez-Laso</name></author><author><name sortKey="Maggi, S" uniqKey="Maggi S">S Maggi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Serra Majem, L" uniqKey="Serra Majem L">L Serra-Majem</name></author><author><name sortKey="Maclean, D" uniqKey="Maclean D">D MacLean</name></author><author><name sortKey="Ribas, L" uniqKey="Ribas L">L Ribas</name></author><author><name sortKey="Brule, D" uniqKey="Brule D">D Brulé</name></author><author><name sortKey="Sekula, W" uniqKey="Sekula W">W Sekula</name></author><author><name sortKey="Prattala, R" uniqKey="Prattala R">R Prattala</name></author><author><name sortKey="Garcia Closas, R" uniqKey="Garcia Closas R">R Garcia-Closas</name></author><author><name sortKey="Yngve, A" uniqKey="Yngve A">A Yngve</name></author><author><name sortKey="Lalonde, M" uniqKey="Lalonde M">M Lalonde</name></author><author><name sortKey="Petrasovits, A" uniqKey="Petrasovits A">A Petrasovits</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bath, Pa" uniqKey="Bath P">PA Bath</name></author><author><name sortKey="Deeg, D" uniqKey="Deeg D">D Deeg</name></author><author><name sortKey="Poppelaars, J" uniqKey="Poppelaars J">J Poppelaars</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sansone, S A" uniqKey="Sansone S">S-A Sansone</name></author><author><name sortKey="Rocca Serra, P" uniqKey="Rocca Serra P">P Rocca-Serra</name></author><author><name sortKey="Field, D" uniqKey="Field D">D Field</name></author><author><name sortKey="Maguire, E" uniqKey="Maguire E">E Maguire</name></author><author><name sortKey="Taylor, C" uniqKey="Taylor C">C Taylor</name></author><author><name sortKey="Hofmann, O" uniqKey="Hofmann O">O Hofmann</name></author><author><name sortKey="Fang, H" uniqKey="Fang H">H Fang</name></author><author><name sortKey="Neumann, S" uniqKey="Neumann S">S Neumann</name></author><author><name sortKey="Tong, W" uniqKey="Tong W">W Tong</name></author><author><name sortKey="Amaral Zettler, L" uniqKey="Amaral Zettler L">L Amaral-Zettler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schad, Pa" uniqKey="Schad P">PA Schad</name></author><author><name sortKey="Mobley, Lr" uniqKey="Mobley L">LR Mobley</name></author><author><name sortKey="Hamilton, Cm" uniqKey="Hamilton C">CM Hamilton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seminara, D" uniqKey="Seminara D">D Seminara</name></author><author><name sortKey="Khoury, Mj" uniqKey="Khoury M">MJ Khoury</name></author><author><name sortKey="O Rien, Tr" uniqKey="O Rien T">TR O’Brien</name></author><author><name sortKey="Manolio, T" uniqKey="Manolio T">T Manolio</name></author><author><name sortKey="Gwinn, Ml" uniqKey="Gwinn M">ML Gwinn</name></author><author><name sortKey="Little, J" uniqKey="Little J">J Little</name></author><author><name sortKey="Higgins, Jpt" uniqKey="Higgins J">JPT Higgins</name></author><author><name sortKey="Bernstein, Jl" uniqKey="Bernstein J">JL Bernstein</name></author><author><name sortKey="Boffetta, P" uniqKey="Boffetta P">P Boffetta</name></author><author><name sortKey="Bondy, M" uniqKey="Bondy M">M Bondy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Budin Lj Sne, I" uniqKey="Budin Lj Sne I">I Budin-Ljøsne</name></author><author><name sortKey="Isaeva, J" uniqKey="Isaeva J">J Isaeva</name></author><author><name sortKey="Knoppers, Bm" uniqKey="Knoppers B">BM Knoppers</name></author><author><name sortKey="Tasse, Am" uniqKey="Tasse A">AM Tassé</name></author><author><name sortKey="Shen, H Y" uniqKey="Shen H">H-y Shen</name></author><author><name sortKey="Mccarthy, Mi" uniqKey="Mccarthy M">MI McCarthy</name></author><author><name sortKey="Harris, Jr" uniqKey="Harris J">JR Harris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bousquet, J" uniqKey="Bousquet J">J Bousquet</name></author><author><name sortKey="Anto, J" uniqKey="Anto J">J Anto</name></author><author><name sortKey="Sunyer, J" uniqKey="Sunyer J">J Sunyer</name></author><author><name sortKey="Nieuwenhuijsen, M" uniqKey="Nieuwenhuijsen M">M Nieuwenhuijsen</name></author><author><name sortKey="Vrijheid, M" uniqKey="Vrijheid M">M Vrijheid</name></author><author><name sortKey="Keil, T" uniqKey="Keil T">T Keil</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harris, Jr" uniqKey="Harris J">JR Harris</name></author><author><name sortKey="Burton, P" uniqKey="Burton P">P Burton</name></author><author><name sortKey="Knoppers, Bm" uniqKey="Knoppers B">BM Knoppers</name></author><author><name sortKey="Lindpaintner, K" uniqKey="Lindpaintner K">K Lindpaintner</name></author><author><name sortKey="Bledsoe, M" uniqKey="Bledsoe M">M Bledsoe</name></author><author><name sortKey="Brookes, Aj" uniqKey="Brookes A">AJ Brookes</name></author><author><name sortKey="Budin Ljosne, I" uniqKey="Budin Ljosne I">I Budin-Ljosne</name></author><author><name sortKey="Chisholm, R" uniqKey="Chisholm R">R Chisholm</name></author><author><name sortKey="Cox, D" uniqKey="Cox D">D Cox</name></author><author><name sortKey="Deschenes, M" uniqKey="Deschenes M">M Deschenes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zika, E" uniqKey="Zika E">E Zika</name></author><author><name sortKey="Paci, D" uniqKey="Paci D">D Paci</name></author><author><name sortKey="Schulte In Den B Umen, T" uniqKey="Schulte In Den B Umen T">T Schulte in den Bäumen</name></author><author><name sortKey="Braun, A" uniqKey="Braun A">A Braun</name></author><author><name sortKey="Rijkers Defrasne, S" uniqKey="Rijkers Defrasne S">S RijKers-Defrasne</name></author><author><name sortKey="Deschenes, M" uniqKey="Deschenes M">M Deschênes</name></author><author><name sortKey="Fortier, I" uniqKey="Fortier I">I Fortier</name></author><author><name sortKey="Laage Hellman, J" uniqKey="Laage Hellman J">J Laage-Hellman</name></author><author><name sortKey="Scerri, Ca" uniqKey="Scerri C">CA Scerri</name></author><author><name sortKey="Ibarreta, D" uniqKey="Ibarreta D">D Ibarreta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gottweis, H" uniqKey="Gottweis H">H Gottweis</name></author><author><name sortKey="Kaye, J" uniqKey="Kaye J">J Kaye</name></author><author><name sortKey="Bignami, F" uniqKey="Bignami F">F Bignami</name></author><author><name sortKey="Rial Sebbag, E" uniqKey="Rial Sebbag E">E Rial-Sebbag</name></author><author><name sortKey="Lattanzi, R" uniqKey="Lattanzi R">R Lattanzi</name></author><author><name sortKey="Macek, M" uniqKey="Macek M">M Macek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bookman, Eb" uniqKey="Bookman E">EB Bookman</name></author><author><name sortKey="Mcallister, K" uniqKey="Mcallister K">K McAllister</name></author><author><name sortKey="Gillanders, E" uniqKey="Gillanders E">E Gillanders</name></author><author><name sortKey="Wanke, K" uniqKey="Wanke K">K Wanke</name></author><author><name sortKey="Balshaw, D" uniqKey="Balshaw D">D Balshaw</name></author><author><name sortKey="Rutter, J" uniqKey="Rutter J">J Rutter</name></author><author><name sortKey="Reedy, J" uniqKey="Reedy J">J Reedy</name></author><author><name sortKey="Shaughnessy, D" uniqKey="Shaughnessy D">D Shaughnessy</name></author><author><name sortKey="Agurs Collins, T" uniqKey="Agurs Collins T">T Agurs-Collins</name></author><author><name sortKey="Paltoo, D" uniqKey="Paltoo D">D Paltoo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khoury, Mj" uniqKey="Khoury M">MJ Khoury</name></author><author><name sortKey="Lam, Tk" uniqKey="Lam T">TK Lam</name></author><author><name sortKey="Ioannidis, Jpa" uniqKey="Ioannidis J">JPA Ioannidis</name></author><author><name sortKey="Hartge, P" uniqKey="Hartge P">P Hartge</name></author><author><name sortKey="Spitz, Mr" uniqKey="Spitz M">MR Spitz</name></author><author><name sortKey="Buring, Je" uniqKey="Buring J">JE Buring</name></author><author><name sortKey="Chanock, Sj" uniqKey="Chanock S">SJ Chanock</name></author><author><name sortKey="Croyle, R" uniqKey="Croyle R">R Croyle</name></author><author><name sortKey="Goddard, Kab" uniqKey="Goddard K">KAB Goddard</name></author><author><name sortKey="Ginsburg, Gs" uniqKey="Ginsburg G">GS Ginsburg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walport, M" uniqKey="Walport M">M Walport</name></author><author><name sortKey="Brest, P" uniqKey="Brest P">P Brest</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pisani, E" uniqKey="Pisani E">E Pisani</name></author><author><name sortKey="Abouzahr, C" uniqKey="Abouzahr C">C AbouZahr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bennett, Sn" uniqKey="Bennett S">SN Bennett</name></author><author><name sortKey="Caporaso, N" uniqKey="Caporaso N">N Caporaso</name></author><author><name sortKey="Fitzpatrick, Al" uniqKey="Fitzpatrick A">AL Fitzpatrick</name></author><author><name sortKey="Agrawal, A" uniqKey="Agrawal A">A Agrawal</name></author><author><name sortKey="Barnes, K" uniqKey="Barnes K">K Barnes</name></author><author><name sortKey="Boyd, Ha" uniqKey="Boyd H">HA Boyd</name></author><author><name sortKey="Cornelis, Mc" uniqKey="Cornelis M">MC Cornelis</name></author><author><name sortKey="Hansel, Nn" uniqKey="Hansel N">NN Hansel</name></author><author><name sortKey="Heiss, G" uniqKey="Heiss G">G Heiss</name></author><author><name sortKey="Heit, Ja" uniqKey="Heit J">JA Heit</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vickers, Aj" uniqKey="Vickers A">AJ Vickers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fortier, I" uniqKey="Fortier I">I Fortier</name></author><author><name sortKey="Burton, Pr" uniqKey="Burton P">PR Burton</name></author><author><name sortKey="Robson, Pj" uniqKey="Robson P">PJ Robson</name></author><author><name sortKey="Ferretti, V" uniqKey="Ferretti V">V Ferretti</name></author><author><name sortKey="Little, J" uniqKey="Little J">J Little</name></author><author><name sortKey="L Eureux, F" uniqKey="L Eureux F">F L’Heureux</name></author><author><name sortKey="Deschenes, M" uniqKey="Deschenes M">M Deschenes</name></author><author><name sortKey="Knoppers, Bm" uniqKey="Knoppers B">BM Knoppers</name></author><author><name sortKey="Doiron, D" uniqKey="Doiron D">D Doiron</name></author><author><name sortKey="Keers, Jc" uniqKey="Keers J">JC Keers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Howe, D" uniqKey="Howe D">D Howe</name></author><author><name sortKey="Costanzo, M" uniqKey="Costanzo M">M Costanzo</name></author><author><name sortKey="Fey, P" uniqKey="Fey P">P Fey</name></author><author><name sortKey="Gojobori, T" uniqKey="Gojobori T">T Gojobori</name></author><author><name sortKey="Hannick, L" uniqKey="Hannick L">L Hannick</name></author><author><name sortKey="Hide, W" uniqKey="Hide W">W Hide</name></author><author><name sortKey="Hill, Dp" uniqKey="Hill D">DP Hill</name></author><author><name sortKey="Kania, R" uniqKey="Kania R">R Kania</name></author><author><name sortKey="Schaeffer, M" uniqKey="Schaeffer M">M Schaeffer</name></author><author><name sortKey="St Pierre, S" uniqKey="St Pierre S">S St Pierre</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Kaye, J" uniqKey="Kaye J">J Kaye</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Knoppers, B" uniqKey="Knoppers B">B Knoppers</name></author><author><name sortKey="Harris, J" uniqKey="Harris J">J Harris</name></author><author><name sortKey="Tasse, A" uniqKey="Tasse A">A Tasse</name></author><author><name sortKey="Budin Ljosne, I" uniqKey="Budin Ljosne I">I Budin-Ljosne</name></author><author><name sortKey="Kaye, J" uniqKey="Kaye J">J Kaye</name></author><author><name sortKey="Deschenes, M" uniqKey="Deschenes M">M Deschenes</name></author><author><name sortKey="Zawati, M" uniqKey="Zawati M">M Zawati</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karr, Af" uniqKey="Karr A">AF Karr</name></author><author><name sortKey="Fulp, Wj" uniqKey="Fulp W">WJ Fulp</name></author><author><name sortKey="Vera, F" uniqKey="Vera F">F Vera</name></author><author><name sortKey="Young, Ss" uniqKey="Young S">SS Young</name></author><author><name sortKey="Lin, X" uniqKey="Lin X">X Lin</name></author><author><name sortKey="Reiter, Jp" uniqKey="Reiter J">JP Reiter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wolfson, M" uniqKey="Wolfson M">M Wolfson</name></author><author><name sortKey="Wallace, Se" uniqKey="Wallace S">SE Wallace</name></author><author><name sortKey="Masca, N" uniqKey="Masca N">N Masca</name></author><author><name sortKey="Rowe, G" uniqKey="Rowe G">G Rowe</name></author><author><name sortKey="Sheehan, Na" uniqKey="Sheehan N">NA Sheehan</name></author><author><name sortKey="Ferretti, V" uniqKey="Ferretti V">V Ferretti</name></author><author><name sortKey="Laflamme, P" uniqKey="Laflamme P">P LaFlamme</name></author><author><name sortKey="Tobin, Md" uniqKey="Tobin M">MD Tobin</name></author><author><name sortKey="Macleod, J" uniqKey="Macleod J">J Macleod</name></author><author><name sortKey="Little, J" uniqKey="Little J">J Little</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muilu, J" uniqKey="Muilu J">J Muilu</name></author><author><name sortKey="Peltonen, L" uniqKey="Peltonen L">L Peltonen</name></author><author><name sortKey="Litton, Je" uniqKey="Litton J">JE Litton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yuille, M" uniqKey="Yuille M">M Yuille</name></author><author><name sortKey="Van Ommen, G J" uniqKey="Van Ommen G">G-J van Ommen</name></author><author><name sortKey="Brechot, C" uniqKey="Brechot C">C Bréchot</name></author><author><name sortKey="Cambon Thomsen, A" uniqKey="Cambon Thomsen A">A Cambon-Thomsen</name></author><author><name sortKey="Dagher, G" uniqKey="Dagher G">G Dagher</name></author><author><name sortKey="Landegren, U" uniqKey="Landegren U">U Landegren</name></author><author><name sortKey="Litton, J E" uniqKey="Litton J">J-E Litton</name></author><author><name sortKey="Pasterk, M" uniqKey="Pasterk M">M Pasterk</name></author><author><name sortKey="Peltonen, L" uniqKey="Peltonen L">L Peltonen</name></author><author><name sortKey="Taussig, M" uniqKey="Taussig M">M Taussig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ford, D" uniqKey="Ford D">D Ford</name></author><author><name sortKey="Jones, K" uniqKey="Jones K">K Jones</name></author><author><name sortKey="Verplancke, J P" uniqKey="Verplancke J">J-P Verplancke</name></author><author><name sortKey="Lyons, R" uniqKey="Lyons R">R Lyons</name></author><author><name sortKey="John, G" uniqKey="John G">G John</name></author><author><name sortKey="Brown, G" uniqKey="Brown G">G Brown</name></author><author><name sortKey="Brooks, C" uniqKey="Brooks C">C Brooks</name></author><author><name sortKey="Thompson, S" uniqKey="Thompson S">S Thompson</name></author><author><name sortKey="Bodger, O" uniqKey="Bodger O">O Bodger</name></author><author><name sortKey="Couch, T" uniqKey="Couch T">T Couch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="El Emam, K" uniqKey="El Emam K">K El Emam</name></author><author><name sortKey="Samet, S" uniqKey="Samet S">S Samet</name></author><author><name sortKey="Arbuckle, L" uniqKey="Arbuckle L">L Arbuckle</name></author><author><name sortKey="Tamblyn, R" uniqKey="Tamblyn R">R Tamblyn</name></author><author><name sortKey="Earle, C" uniqKey="Earle C">C Earle</name></author><author><name sortKey="Kantarcioglu, M" uniqKey="Kantarcioglu M">M Kantarcioglu</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Karelis, Ad" uniqKey="Karelis A">AD Karelis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Denis, Gv" uniqKey="Denis G">GV Denis</name></author><author><name sortKey="Obin, Ms" uniqKey="Obin M">MS Obin</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Fortier, I" uniqKey="Fortier I">I Fortier</name></author><author><name sortKey="Doiron, D" uniqKey="Doiron D">D Doiron</name></author><author><name sortKey="Little, J" uniqKey="Little J">J Little</name></author><author><name sortKey="Ferretti, V" uniqKey="Ferretti V">V Ferretti</name></author><author><name sortKey="L Eureux, F" uniqKey="L Eureux F">F L’Heureux</name></author><author><name sortKey="Stolk, Rp" uniqKey="Stolk R">RP Stolk</name></author><author><name sortKey="Knoppers, Bm" uniqKey="Knoppers B">BM Knoppers</name></author><author><name sortKey="Hudson, Tj" uniqKey="Hudson T">TJ Hudson</name></author><author><name sortKey="Burton, Pr" uniqKey="Burton P">PR Burton</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Doiron, D" uniqKey="Doiron D">D Doiron</name></author><author><name sortKey="Raina, P" uniqKey="Raina P">P Raina</name></author><author><name sortKey="Ferretti, V" uniqKey="Ferretti V">V Ferretti</name></author><author><name sortKey="L Eureux, F" uniqKey="L Eureux F">F L’Heureux</name></author><author><name sortKey="Fortier, I" uniqKey="Fortier I">I Fortier</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Knoppers, B" uniqKey="Knoppers B">B Knoppers</name></author><author><name sortKey="Fortier, I" uniqKey="Fortier I">I Fortier</name></author><author><name sortKey="Legault, D" uniqKey="Legault D">D Legault</name></author><author><name sortKey="Burton, P" uniqKey="Burton P">P Burton</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Flanagan, D" uniqKey="Flanagan D">D Flanagan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jones, E" uniqKey="Jones E">E Jones</name></author><author><name sortKey="Sheehan, N" uniqKey="Sheehan N">N Sheehan</name></author><author><name sortKey="Masca, N" uniqKey="Masca N">N Masca</name></author><author><name sortKey="Wallace, S" uniqKey="Wallace S">S Wallace</name></author><author><name sortKey="Murtagh, M" uniqKey="Murtagh M">M Murtagh</name></author><author><name sortKey="Burton, P" uniqKey="Burton P">P Burton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sutton, Aj" uniqKey="Sutton A">AJ Sutton</name></author><author><name sortKey="Kendrick, D" uniqKey="Kendrick D">D Kendrick</name></author><author><name sortKey="Coupland, Cac" uniqKey="Coupland C">CAC Coupland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gomatam, S" uniqKey="Gomatam S">S Gomatam</name></author><author><name sortKey="Karr, Af" uniqKey="Karr A">AF Karr</name></author><author><name sortKey="Reiter, Jp" uniqKey="Reiter J">JP Reiter</name></author><author><name sortKey="Sanil, Ap" uniqKey="Sanil A">AP Sanil</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>Finlande</li><li>Italie</li><li>Norvège</li><li>Pays-Bas</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Groningue (province)</li><li>Québec</li><li>Trøndelag</li><li>Uusimaa</li></region><settlement><li>Groningue</li><li>Helsinki</li><li>Londres</li><li>Montréal</li><li>Trondheim</li></settlement><orgName><li>Université d'Helsinki</li><li>Université de Groningue</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Doiron, Dany" sort="Doiron, Dany" uniqKey="Doiron D" first="Dany" last="Doiron">Dany Doiron</name></noRegion><name sortKey="Doiron, Dany" sort="Doiron, Dany" uniqKey="Doiron D" first="Dany" last="Doiron">Dany Doiron</name><name sortKey="Ferretti, Vincent" sort="Ferretti, Vincent" uniqKey="Ferretti V" first="Vincent" last="Ferretti">Vincent Ferretti</name><name sortKey="Fortier, Isabel" sort="Fortier, Isabel" uniqKey="Fortier I" first="Isabel" last="Fortier">Isabel Fortier</name><name sortKey="Marcon, Yannick" sort="Marcon, Yannick" uniqKey="Marcon Y" first="Yannick" last="Marcon">Yannick Marcon</name><name sortKey="Tasse, Anne Marie" sort="Tasse, Anne Marie" uniqKey="Tasse A" first="Anne-Marie" last="Tassé">Anne-Marie Tassé</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Burton, Paul" sort="Burton, Paul" uniqKey="Burton P" first="Paul" last="Burton">Paul Burton</name></noRegion><name sortKey="Gaye, Amadou" sort="Gaye, Amadou" uniqKey="Gaye A" first="Amadou" last="Gaye">Amadou Gaye</name><name sortKey="Minelli, Cosetta" sort="Minelli, Cosetta" uniqKey="Minelli C" first="Cosetta" last="Minelli">Cosetta Minelli</name></country><country name="Pays-Bas"><region name="Groningue (province)"><name sortKey="Wolffenbuttel, Bruce H R" sort="Wolffenbuttel, Bruce H R" uniqKey="Wolffenbuttel B" first="Bruce H R" last="Wolffenbuttel">Bruce H R. Wolffenbuttel</name></region><name sortKey="Hillege, Hans L" sort="Hillege, Hans L" uniqKey="Hillege H" first="Hans L" last="Hillege">Hans L. Hillege</name><name sortKey="Stolk, Ronald P" sort="Stolk, Ronald P" uniqKey="Stolk R" first="Ronald P" last="Stolk">Ronald P. Stolk</name></country><country name="Finlande"><noRegion><name sortKey="Perola, Markus" sort="Perola, Markus" uniqKey="Perola M" first="Markus" last="Perola">Markus Perola</name></noRegion><name sortKey="Perola, Markus" sort="Perola, Markus" uniqKey="Perola M" first="Markus" last="Perola">Markus Perola</name></country><country name="Italie"><noRegion><name sortKey="Foco, Luisa" sort="Foco, Luisa" uniqKey="Foco L" first="Luisa" last="Foco">Luisa Foco</name></noRegion></country><country name="Allemagne"><noRegion><name sortKey="Waldenberger, Melanie" sort="Waldenberger, Melanie" uniqKey="Waldenberger M" first="Melanie" last="Waldenberger">Melanie Waldenberger</name></noRegion><name sortKey="Holle, Rolf" sort="Holle, Rolf" uniqKey="Holle R" first="Rolf" last="Holle">Rolf Holle</name></country><country name="Norvège"><region name="Trøndelag"><name sortKey="Kval Y, Kirsti" sort="Kval Y, Kirsti" uniqKey="Kval Y K" first="Kirsti" last="Kval Y">Kirsti Kval Y</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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